An Original Traceless Linker Strategy for Solid‐Phase

linker or spacer specially adapted for combinatorial chemistry or a library (e.g., traceless linker, safety-catch linker, etc.): This subclass is indented under the class definition . Subject matter for use in combinatorial chemistry techniques which involves a chemical constituent which is used to connect a compound to a support or another An Original Traceless Linker Strategy for Solid‐Phase Mar 03, 2000 Conjugation Chemistry-Dependent T-Cell Activation with A comparison of three linker types, (1) noncleavable, (2) cleavable but nontraceless, and (3) traceless, reveals up to an 8-fold improvement in T-cell proliferation when the traceless linker is used. This work underscores the critical importance of the choice of conjugation chemistry in vaccine development.

Also, lysosomal extract incubation with LCB14-0302 clearly demonstrated the traceless toxin release by β-glucuronidase regardless of other enzymatic disturbance. Therefore, these results strongly suggest that LBG-linker is highly stable and specific to β-glucuronidase among hundreds of enzymes in the lysosome.

Synthesis of silicon traceless linker for solid-phase The silicon linker is the foremost traceless linker used in solid-phase reactions. Hydrogen fluoride (HF) or trifluoroacetic aicd (TFA) can remove the silicon linker with the silicon atom being replaced by a hydrogen atom. In this experiment, the linkers 1c and 2d, which are the most useful in solid-phase reactions, were synthesized.

May 31, 2016

A traceless photocleavable linker for the automated glycan